Endocrine Abstracts

Introduction: Some metabolic diseases, including type 1 (T1DM) and type 2 (T2DM) diabetes mellitus have an influence on bone homeostasis. These facts are of great socio-medical impact, since currently the DM2 and osteoporosis are considered public health problems.Objectives: (1) Determine the relationship between markers of bone metabolism and insulin resistance in postmenopausal women with and without T2DM.(2) Compare the bone min...

Introduction: Primary hyperparathyroidism (PHPT) is emerging as a cause of secondary hypertension. Between 20 and 50% of patients with PHPT have hypertension, this being directly proportional to the calcemia. The elevation of blood pressure in PHPT is mediated by hypercalcemia that acts directly stimulating the contraction of muscle fibers of the arterial vessel wall, and increases plasma renin levels and the release of catecholamines.Objectives: (1) Det...

Pseudohypoparathyroidism (PHP) refers to a group of heterogeneous genetic diseases, characterized by resistance to PTH and frequently other hormones activating cAMP-dependent events down-stream of different G protein-coupled receptors. PHP-Ia and Ib, the most frequent forms, are caused by mutations within the GNAS locus that encodes Gαs and several splice variants thereof. We describe a 36-year-old man with sporadic PHP-Ib with renal PTH-resistance, yet severe hyperparath...

Introduction: Patients with resistance to thyroid hormone (RTH) have variable tissue hyporesponsiveness to thyroid hormone (TH) due to a defect in the TH receptor (TR) β gene. So far, 124 different mutations have been identified among 343 unrelated families. Despite the TH resistance, some patients have symptoms and signs of hyperthyroidism and may have goiter. RTH is characterised by high TH and normal or high TSH concentrations. Differential diagnosis includes a TSH-pro...

Introduction: Gender identity disorder (GID) is a disagreement between biological sexual differentiation and self-declared gender identity. The aetiology of GID remains unclear, although endocrinological, neuroanatomical and psychosocial factors are all thought to be causally involved. Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, polycystic ovarian morphology, and biochemical and/or biological signs of hyperandrogenism. Most women with PCOS also ex...

Introduction: Transsphenoidal surgery is the preferred approach in patients with pituitary tumours. Transsphenoidal resection of pituitary tumors may account for as much as 20% of all intracranial operations performed for primary brain tumors. Meningitis is a rare complication accounting for less than 2% of procedures.Methods: We report the case of an elderly patient with a sellar mass who was admitted to the hospital with a central nerve system infectio...

Introduction: Abiraterone acetate, potent selective irreversible inhibitor of CYP17A1, is increasingly used with prednisone to treat prostate cancer resistant to androgen deprivation therapy.Case Presentation: 64-year-old gentleman with BG of prostate cancer with widespread metastatic bone disease. He was on abiraterone since 2019. Admitted with generally unwell, aches/pains, headache, and dizziness. Euvolemic hyponatrem...

Introduction: Acute Colonic Pseudo-Obstruction (Ogilvie’s syndrome) is characterized by colonic distention in the absence of mechanical obstruction. Those without ischaemia/perforation is treated conservatively by withdrawing offending drugs, correcting electrolytes/underlying risk factors, neostigmine and colonic decompression.Case Presentation: 90-year-old frail lady from care home with HTN, CVA, and dementia, adm...

Introduction: EAS is an endocrine emergency requiring emergency diagnosis/treatment. Bronchial carcinoid is known to cause EAS and carcinoid syndrome (without liver involvement).Clinical features: 58-year-old lady with COPD and fibromyalgia referred as 2WW pathway with abdominal pain, diarrhoea, and weight loss. Investigated with CT-CAP: inflammatory looking 7mm lung nodule left upper lobe, enlarged left hilar, aorto-pul...

Introduction: Thyroid storm presents as multiorgan dysfunction. Diagnosis is purely clinical, and early diagnosis improves the outcomes.Case Presentation: 45-year-old lady without significant illness presented with breathlessness, productive cough, anxiety, and weight loss. Chest x-ray showed right pleural effusion and left consolidation. She was in fast AF with NT-proBNP >27000. initially treated as chest sepsis wit...